d-Glucose and d-mannose-based metabolic probes. Part 3: Synthesis of specifically deuterated d-glucose, d-mannose, and 2-deoxy-d-glucose
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منابع مشابه
Synthesis of D-Glucose-1-C14 and D-Mannose-1-C14
Heretofore, radiochemical yields of sugars position-labeled with carbon-14 have been only 5 to 10 percent. This paper reports an improved cyanohydrin synthesis, and the preparation of D-glucose-1-C and D-mannose-1-C from D-arabinose in yields of about 50 percent. Low yields in prior syntheses appear to have been due to several inefficient steps, and to the fact that extension of the carbon chai...
متن کاملEntrapment–D-(+)-Glucose Water Nanodroplet: Synthesis and Dynamic Light Scattering
In the present research, the D-(+)-Glucose–confined water nanodroplets with mean size in the range of 6-11 nm were synthesized at D-(+)-Glucose different concentrations by AOT reverse micelles (RMs) method as a function of mass fraction of droplet (MFD) at the constant water-to-surfactant molar ratio ( W=40). The dynamic light scattering of the nano-sized water droplets containing the D-(+)-Glu...
متن کاملAntiangiogenic Activity of 2-Deoxy-D-Glucose
BACKGROUND During tumor angiogenesis, endothelial cells (ECs) are engaged in a number of energy consuming biological processes, such as proliferation, migration, and capillary formation. Since glucose uptake and metabolism are increased to meet this energy need, the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) on in vitro and in vivo angiogenesis were investigated. METHODOLOGY...
متن کاملReactions of Saccharides Catalyzed by Molybdate Ions. II.* Epimerization of D-Glucose and D-Mannose
In acidified water solutions of molybdate, aldoses epimerize under the formation of equilibrium mixtures in which the epimer having trans relationship of the hydroxyl groups at C-2 and C-3 predominates. The epimerization of both D-glucose and D-mannose gives the equilibrium mixture of D-glucose and D-mannose in the ratio 75 25. A tentative mechanism for this reaction is suggested and the prepar...
متن کاملD-mannose as a preservative of glucose in blood samples.
We studied the changes in blood glucose concentration in blood samples collected in heparinized specimen tubes containing no other preservative, or containing NaF, D-mannose, or a combination of NaF and D-mannose. Blood concentration in samples taken into NaF decreased by 0.40 mmol/L in the first 2 h; thereafter, there was no change. In samples collected into mannose there was a small but signi...
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ژورنال
عنوان ژورنال: Carbohydrate Research
سال: 2013
ISSN: 0008-6215
DOI: 10.1016/j.carres.2012.11.021